Leader: Melissa Kemp

Working Group Collaborators: Melissa Kemp (GT), Todd McDevitt (Gladstone), Calin Belta (BU), Laurie Boyer (MIT), Linda Griffith (MIT), Mike Levin (Tufts), Ron Weiss (MIT), Shu Takayama (GT), Stas Shvartsman (Princeton), Hang Lu (GT)

Working Group Goals

The goals of this Working Group are to: 1) identify and control the extrinsic and intrinsic parameters governing the initiation of emergent behaviors of multicellular systems, and 2) examine the spatiotemporal dynamics of emergent behaviors that arise from asymmetric patterning events that occur at the very earliest stages of cell differentiation and self- organization; 3) explore and model the formation of organoids in vitro and the formation of functional structures in natural systems and 4) to direct the co-differentiation of pluripotent stem cells to achieve controlled spatial patterning of multicellular constructs by harnessing biochemical, bioelectrical, and biophysical cues with a focus on subsequent steps towards organoid formation.