Vascularization

The goal of the Microvascular Networks research is to design and construct functional microvascular networks for use in the next generation of biological machines. 

These networks must be large enough to require a circulation in order to meet the metabolic needs of the other cell types. Currently, differentiated cell lines are being used in microfluidic devices to create networks that span a distance of up to 1 mm and can be perfused from side channels. Mouse ES cells and mouse and human MSCs are also being developed that could be used both for the endothelial network and for the pericytes and smooth muscle cells presumably needed for long-term viability and phenotypic stability.

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